 |
| Research article summary (published 29 Apr 2009): |
|
Free Full Text! See links below |
Contribution of prior semantic knowledge to new episodic learning in amnesia.
Full Abstract
We evaluated whether prior semantic knowledge would enhance episodic learning in amnesia. Subjects studied prices that are either congruent or incongruent with prior price knowledge for grocery and household items and then performed a forced-choice recognition test for the studied prices. Consistent with a previous report, healthy controls' performance was enhanced by price knowledge congruency; however, only a subset of amnesic patients experienced the same benefit. Whereas patients with relatively intact semantic systems, as measured by an anatomical measure (i.e., lesion involvement of anterior and lateral temporal lobes), experienced a significant congruency benefit, patients with compromised semantic systems did not experience a congruency benefit. Our findings suggest that when prior knowledge structures are intact, they can support acquisition of new episodic information by providing frameworks into which such information can be incorporated.
Author information
Author/s: Kan, Irene P (IP); Alexander, Michael P (MP); Verfaellie, Mieke (M);
Affiliation: Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, USA. irene.kan(-atsign-)villanova.edu
Grants: HD 046442 (Agency:NICHD NIH HHS) ; MH 57681 (Agency:NIMH NIH HHS) ; MH 71783 (Agency:NIMH NIH HHS) ; R01 MH057681-10 (Agency:NIMH NIH HHS) ; R01 MH071783-02 (Agency:NIMH NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal: Journal of cognitive neuroscience (J Cogn Neurosci), published in United States. (Language: eng)
Reference: 2009-May; vol 21 (issue 5) : pp 938-44
Dates: Created 2009/04/09; Completed 2009/06/04;
PMID: 18702596, status: MEDLINE (last retrieval date: 6/4/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article
(including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.