Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting.

Full Abstract

This overview describes the goals and objectives of the third conference conducted as part of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. This third conference was focused on selecting specific paradigms from cognitive neuroscience that measured the constructs identified in the first CNTRICS meeting, with the goal of facilitating the translation of these paradigms into use in clinical trials contexts. To identify such paradigms, we had an open nomination process in which the field was asked to nominate potentially relevant paradigms and to provide information on several domains relevant to selecting the most promising tasks for each construct (eg, construct validity, neural bases, psychometrics, availability of animal models). Our goal was to identify 1-2 promising tasks for each of the 11 constructs identified at the first CNTRICS meeting. In this overview article, we describe the on-line survey used to generate nominations for promising tasks, the criteria that were used to select the tasks, the rationale behind the criteria, and the ways in which breakout groups worked together to identify the most promising tasks from among those nominated. This article serves as an introduction to the set of 6 articles included in this special issue that provide information about the specific tasks discussed and selected for the constructs from each of 6 broad domains (working memory, executive control, attention, long-term memory, perception, and social cognition).

Author information

Author/s: Barch, Deanna M (DM); Carter, Cameron S (CS); Arnsten, Amy (A); Buchanan, Robert W (RW); Cohen, Jonathan D (JD); Geyer, Mark (M); Green, Michael F (MF); Krystal, John H (JH); Nuechterlein, Keith (K); Robbins, Trevor (T); Silverstein, Steven (S); Smith, Edward E (EE); Strauss, Milton (M); Wykes, Til (T); Heinssen, Robert (R);

Affiliation: Washington University, St. Louis, MO, USA. dbarch(-atsign-)artsci.wustl.edu

Journal and publication information

Publication Type: Congresses; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Schizophrenia bulletin (Schizophr Bull), published in United States. (Language: eng)

Reference: 2009-Jan; vol 35 (issue 1) : pp 109-14

Dates: Created 2008/12/16; Completed 2009/03/30;

PMID: 19023126, status: MEDLINE (last retrieval date: 3/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a large map of 100+ related articles.