Research article summary (published 30 May 2009):

Improved effect of Pycnogenol on impaired spatial memory function in partial androgen deficiency rat model.

Full Abstract

The improved effect of Pycnogenol on impaired spatial memory function was studied in orchidectomized rats. Endogenous testosterone levels were decreased by approximately one-half for 3 months after castration. In the radial arm maze, castration significantly impaired working and reference memory function without lowering motor function. Pycnogenol increased the NGF content in the hippocampus and cortex, and improved the spatial memory impairment. These observations confirmed that diagnostic accuracy can be improved by Pycnogenol in androgen-deficient rats. (c) 2009 John Wiley & Sons, Ltd.

Author information

Author/s: Hasegawa, Noboru (N); Mochizuki, Miyako (M);

Affiliation: Department of Health and Nutrition, Faculty of Home Economics, Gifu Women's University, Gifu, Japan. hsgwn(-atsign-)gijodai.ac.jp

Journal and publication information

Publication Type: Journal Article

Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)

Reference: 2009-Jun; vol 23 (issue 6) : pp 840-3

Dates: Created 2009/05/27; Completed 2009/06/17;

PMID: 19142987, status: MEDLINE (last retrieval date: 6/17/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Androgens - deficiency Animals Flavonoids - pharmacology Hippocampus - metabolism Male Maze Learning - drug effects Memory - drug effects

Memory Disorders - drug therapy Motor Activity - drug effects Nerve Growth Factors - metabolism Orchiectomy Rats Rats, Sprague-Dawley Testosterone - blood; deficiency

Associated Chemicals: Androgens (0) ; Flavonoids (0) ; Nerve Growth Factors (0) ; pycnogenols (0) ; Testosterone (58-22-0)

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