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Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.
Full Abstract
A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats. An RT-PCR study further showed that mRNA expression of CYP2B was maximal at 6 h. Plasma and liver bilobalide concentration in rats following administration of Ginkgo biloba extract equivalent to bilobalide of approximately 40 mg/kg showed a similar response to that exhibited by mRNA expression. These findings suggest that bilobalide markedly induced hepatic CYPs, but the induction could be mitigated due to rapid elimination from the liver.
Author information
Author/s: Taki, Yuko (Y); Yamazaki, Yuko (Y); Shimura, Fumio (F); Yamada, Shizuo (S); Umegaki, Keizo (K);
Affiliation: National Institute of Health and Nutrition, Japan.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of pharmacological sciences (J Pharmacol Sci), published in Japan. (Language: eng)
Reference: 2009-Mar; vol 109 (issue 3) : pp 459-62
Dates: Created 2009/03/23; Completed 2009/05/26;
PMID: 19276617, status: MEDLINE (last retrieval date: 5/26/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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