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| Research article summary (published 30 Mar 2009): |
Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
Full Abstract
The serotonin 5-HT2A receptor (5-HT-sub(2A)R) may play a role in reinstatement of drug-seeking. This study investigated the ability of a selective 5-HT-sub(2A)R antagonist to suppress reinstatement evoked by exposure to cues conditioned to cocaine self-administration. Cocaine self-administration (0.75 mg/kg/0.1 mL/6 s infusion; FR 4) was trained in naïve, free-fed rats to allow interpretation of results independent from changes related to food deprivation stress. Pretreatment with the selective 5-HT-sub(2A)R antagonist M100907 (volinanserin) failed to reduce rates of operant responding for cocaine infusions. On the other hand, M100907 (0.001-0.8 mg/kg ip) significantly suppressed the cue-induced reinstatement of cocaine-seeking behavior following extinction; effective M100907 doses did not alter operant responding for cues previously associated with sucrose self-administration. Importantly, a greater magnitude of active lever presses on the initial extinction session (high extinction responders) predicted the maximal susceptibility to M100907-induced suppression of cue-evoked reinstatement. The findings indicate that blockade of the 5-HT-sub(2A)R attenuates the incentive-motivational effects of cocaine-paired cues, particularly in high extinction responders, and suggests that M100907 may afford a therapeutic advance in suppression of cue-evoked craving and/or relapse. (c) 2009 APA, all rights reserved.
Author information
Author/s: Nic Dhonnchadha, B A (BA); Fox, R G (RG); Stutz, S J (SJ); Rice, K C (KC); Cunningham, K A (KA);
Affiliation: Center for Addiction Research, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550-1031, USA.
Grants: DA 00260 (Agency:NIDA NIH HHS) ; DA 020087 (Agency:NIDA NIH HHS) ; DA 06511 (Agency:NIDA NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)
Reference: 2009-Apr; vol 123 (issue 2) : pp 382-96
Dates: Created 2009/03/31; Completed 2009/05/18;
PMID: 19331461, status: MEDLINE (last retrieval date: 5/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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