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| Research article summary (published 25 May 2009): |
Short-latency influence of medial frontal cortex on primary motor cortex during action selection under conflict.
Full Abstract
Medial frontal cortex (MFC) is crucial when actions have to be inhibited, reprogrammed, or selected under conflict, but the precise mechanism by which it operates is unclear. Importantly, how and when the MFC influences the primary motor cortex (M1) during action selection is unknown. Using paired-pulse transcranial magnetic stimulation, we investigated functional connectivity between the presupplementary motor area (pre-SMA) part of MFC and M1. We found that functional connectivity increased in a manner dependent on cognitive context: pre-SMA facilitated the motor evoked-potential elicited by M1 stimulation only during action reprogramming, but not when otherwise identical actions were made in the absence of conflict. The effect was anatomically specific to pre-SMA; it was not seen when adjacent brain regions were stimulated. We discuss implications for the anatomical pathways mediating the observed effects.
Author information
Author/s: Mars, Rogier B (RB); Klein, Miriam C (MC); Neubert, Franz-Xaver (FX); Olivier, Etienne (E); Buch, Ethan R (ER); Boorman, Erie D (ED); Rushworth, Matthew F S (MF);
Affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom. rogier.mars(-atsign-)psy.ox.ac.uk
Grants: (Agency:Medical Research Council)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2009-May; vol 29 (issue 21) : pp 6926-31
Dates: Created 2009/05/28; Completed 2009/06/23;
PMID: 19474319, status: MEDLINE (last retrieval date: 6/23/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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