Research article summary (published 29 Sep 2009):

Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.

Full Abstract

A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The HNSCC risk also increased several folds in cases with combination of variant genotypes of CYP1A1*2A or CYP1A1*2C with null genotype of glutathione-S-transferase M1 (GSTM1), a phase II enzyme, particularly in cases who were tobacco users (smokers and tobacco chewers), demonstrating the role of gene-gene and gene-environment interactions in the development of HNSCC.

Author information

Author/s: Singh, Arvind P (AP); Shah, Parag P (PP); Ruwali, Munindra (M); Mathur, Neeraj (N); Pant, Mohan C (MC); Parmar, Devendra (D);

Affiliation: Indian Institute of Toxicology Research, Lucknow, India.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Cancer investigation (Cancer Invest), published in England. (Language: eng)

Reference: 2009-Oct; vol 27 (issue 8) : pp 869-76

Dates: Created 2009/09/04; Completed 2009/09/17;

PMID: 19639480, status: MEDLINE (last retrieval date: 9/17/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Carcinoma, Squamous Cell - enzymology; genetics Case-Control Studies Cytochrome P-450 CYP1A1 - genetics Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Glutathione Transferase - genetics Head and Neck Neoplasms - enzymology; genetics Humans

Humans India Logistic Models Male Middle Aged Odds Ratio Polymorphism, Genetic Risk Assessment Risk Factors Smoking - adverse effects Tobacco, Smokeless - adverse effects

Associated Chemicals: Cytochrome P-450 CYP1A1 (EC 1.14.14.1) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18)

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