Research article summary (published 29 Sep 2009):

CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta.

Full Abstract

Placenta as an ideal model to study angiogenic mechanisms have been established in previous studies. There are two processes, vasculogenesis and angiogenesis, involved in blood vessel formation during placental development. Therefore, blood vessel formation is a crucial issue that might cause vascular malformations. One of the vascular malformations is cerebral cavernous malformation (CCM) in the central nervous system, consisting of endothelium-lined vascular channels without intervening normal brain parenchyma. Three CCM loci have been mapped as Ccm1, Ccm2, Ccm3 genes in CCM. In order to investigate whether CCM proteins participate in blood vessel formation, we report here the expression patterns of CCM2 and CCM3 in developing and term human placenta by means of immunohistochemistry and Western blot analysis. CCM2 and CCM3 were obviously detected in the vascular endothelium during early pregnancy. Moreover, vascular endothelium of stem villi revealed a moderate immunostaining for CCM2 and, to a lesser extent, in the endothelium of mature intermediate villi in term placenta. Interestingly, CCM3 immuno-staining was weakly localized in the endothelium of mature intermediate villi and showed lesser expression going toward stem villi in term placenta. The expression patterns of the proteins were clearly identified in the vascular endothelium of human placenta, suggesting that they might play roles during angiogenesis and vasculogenesis. Furthermore, with this study, CCM2 and CCM3 have been described for the first time in the human placenta.

Author information

Author/s: Tanriover, Gamze (G); Seval, Yasemin (Y); Sati, Leyla (L); Gunel, Murat (M); Demir, Necdet (N);

Affiliation: Department of Histology and Embryology, Akdeniz University, School of Medicine, Antalya, Turkey.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Histology and histopathology (Histol Histopathol), published in Spain. (Language: eng)

Reference: 2009-Oct; vol 24 (issue 10) : pp 1287-94

Dates: Created 2009/08/18; Completed 2009/11/03;

PMID: 19688696, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Apoptosis Regulatory Proteins - genetics; metabolism Carrier Proteins - genetics; metabolism Case-Control Studies Central Nervous System Neoplasms - metabolism Female Hemangioma, Cavernous, Central Nervous System - metabolism Humans Immunohistochemistry

Immunohistochemistry Membrane Proteins - genetics; metabolism Neovascularization, Pathologic Placenta - metabolism Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Proto-Oncogene Proteins - genetics; metabolism

Associated Chemicals: Apoptosis Regulatory Proteins (0) ; CCM2 protein, human (0) ; Carrier Proteins (0) ; Membrane Proteins (0) ; PDCD10 protein, human (0) ; Proto-Oncogene Proteins (0)

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