A pilot study comparing the diabetogenic effects of dexamethasone and prednisolone in cats.

Full Abstract

Fourteen cats received either daily prednisolone (4.4 mg/kg per os [PO]) or dexamethasone (0.55 mg/kg PO) for 56 days. These doses were clinically equipotent. Serum fructosamine and urine glucose were measured on days 0, 28, and 56. Insulin sensitivity, glucose tolerance, and peak insulin secretion were measured in each group prior to and at the end of the courses of glucocorticoid administration. On day 56, the prevalence of glucosuria was significantly greater (P=0.027), and a trend was seen toward greater fructosamine concentrations (P=0.083) in dexamethasone-treated cats compared to prednisolone-treated cats. The results of this pilot study also showed a trend toward a greater decrease in insulin sensitivity (P=0.061) and a significantly lower compensatory increase in insulin secretion (P=0.081) in the dexamethasone-treated cats than in cats administered prednisolone. These preliminary data suggest that dexamethasone exhibits greater diabetogenic effects in cats than equipotent doses of prednisolone. Further study is justified to support this hypothesis.

Author information

Author/s: Lowe, Andrew D (AD); Graves, Thomas K (TK); Campbell, Karen L (KL); Schaeffer, David J (DJ);

Affiliation: Department of Veterinary Clinical Medicine, University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61834, USA.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of the American Animal Hospital Association (J Am Anim Hosp Assoc), published in United States. (Language: eng)

Reference: -2009 Sep-Oct; vol 45 (issue 5) : pp 215-24

Dates: Created 2009/09/02; Completed 2009/10/30;

PMID: 19723844, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Oral
Animals
Blood Glucose - analysis
Cat Diseases - chemically induced
Cats
Dexamethasone - administration & dosage; adverse effects; pharmacology
Diabetes Mellitus - chemically induced; veterinary
Fructosamine - blood

Fructosamine - blood
Glucocorticoids - administration & dosage; pharmacology
Glycosuria - chemically induced; veterinary
Insulin - metabolism; secretion
Male
Pilot Projects
Prednisolone - administration & dosage; adverse effects; pharmacology
Random Allocation

Associated Chemicals: Blood Glucose (0) ; Glucocorticoids (0) ; Insulin (11061-68-0) ; Fructosamine (4429-04-3) ; Dexamethasone (50-02-2) ; Prednisolone (50-24-8)

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