Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

Full Abstract

Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Author information

Author/s: Nemec, Petr (P); Goldbergova, Monika Pavkova (MP); Gatterova, Jindra (J); Vasku, Anna (A); Soucek, Miroslav (M);

Affiliation: Rheumatology Division, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic. petr.nemec(-atsign-)fnusa.cz

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 501-8

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758192, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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