Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members.

Full Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

Author information

Author/s: Krause, Ilan (I); Anaya, Juan Manuel (JM); Fraser, Abigail (A); Barzilai, Ori (O); Ram, Maya (M); Abad, Verónica (V); Arango, Alvaro (A); García, Jorge (J); Shoenfeld, Yehuda (Y);

Affiliation: Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

Journal and publication information

Publication Type: Journal Article

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 633-9

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758209, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Animals
Antibodies, Bacterial - blood
Antibodies, Protozoan - blood
Antibodies, Viral - blood
Autoantibodies - blood
Autoimmunity - immunology
Child
Cytomegalovirus - immunology
Diabetes Mellitus, Type 1 - blood; immunology
Family Health
Female

Gliadin - immunology
Helicobacter Infections - immunology
Helicobacter pylori - immunology
Herpesvirus 4, Human - immunology
Humans
Immunoglobulin G - blood
Male
Toxoplasma - immunology
Toxoplasmosis - immunology
Transglutaminases - immunology
Virus Diseases - immunology
Young Adult

Associated Chemicals: Antibodies, Bacterial (0) ; Antibodies, Protozoan (0) ; Antibodies, Viral (0) ; Autoantibodies (0) ; Immunoglobulin G (0) ; Gliadin (9007-90-3) ; Transglutaminases (EC 2.3.2.13) ; tissue transglutaminase 2, human (EC 2.3.2.13)

These are the highest related articles currently in the database: