Periodontal therapy improves gastric Helicobacter pylori eradication.

Full Abstract

The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alone. Our results indicate that 77.3% of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 47.6% who underwent only triple therapy. Analysis of these data suggests that periodontal treatment in combination with systemic therapy could be a promising approach to increasing the therapy's efficacy and decreasing the risk of infection recurrence.

Author information

Author/s: Zaric, S (S); Bojic, B (B); Jankovic, Lj (Lj); Dapcevic, B (B); Popovic, B (B); Cakic, S (S); Milasin, J (J);

Affiliation: Clinic of Periodontology and Oral Medicine, School of Dentistry, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Journal of dental research (J Dent Res), published in United States. (Language: eng)

Reference: 2009-Oct; vol 88 (issue 10) : pp 946-50

Dates: Created 2009/09/28; Completed 2009/11/02;

PMID: 19783805, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Helicobacter Infections - drug therapy
Helicobacter pylori - physiology
Humans
Male
Middle Aged
Periodontal Attachment Loss - microbiology
Periodontal Diseases - microbiology; therapy
Periodontal Pocket - microbiology
Prospective Studies
Proton Pump Inhibitors - therapeutic use
Recurrence
Root Planing
Stomach Diseases - drug therapy; microbiology
Young Adult

Associated Chemicals: 2-Pyridinylmethylsulfinylbenzimidazoles (0) ; Anti-Bacterial Agents (0) ; Anti-Infective Agents (0) ; Anti-Infective Agents, Local (0) ; Proton Pump Inhibitors (0) ; pantoprazole (102625-70-7) ; chlorhexidine gluconate (18472-51-0) ; Amoxicillin (26787-78-0) ; Chlorhexidine (55-56-1) ; Clarithromycin (81103-11-9) ; H(+)-K(+)-Exchanging ATPase (EC 3.6.1.10)

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