Changes in tumor volume of sacral chordoma after carbon ion radiotherapy.

Full Abstract

OBJECTIVE: We evaluated changes in tumor volume in cases of sacral chordoma after carbon ion radiotherapy. METHODS: Thirty-four patients with sacral chordoma underwent carbon ion radiotherapy between June 1996 and June 2003. We assessed 23 patients without previous surgery using T2-weighted magnetic resonance imaging. The tumor volume was calculated semiautomatically. RESULTS: Two cases showed local recurrence. The median interval of this examination was 46 months. At the end of the treatment, the tumor showed an enlargement larger than 10% of its volume in 13 of the 23 cases, no change in 4 cases, and regression in 6 cases. At the last examination, 20 cases showed a reduction in tumor volume, and the median ratio, determined as the tumor volume at the last examination divided by that before the treatment, was 0.36. CONCLUSIONS: An increase in tumor volume at the end of the treatment does not indicate the ineffectiveness of carbon ion radiotherapy.

Author information

Author/s: Serizawa, Itsuko (I); Imai, Reiko (R); Kamada, Tadashi (T); Tsuji, Hiroshi (H); Kishimoto, Riwa (R); Kandatsu, Susumu (S); Tsujii, Hirohiko (H); Tatezaki, Shin-Ichiro (S);

Affiliation: Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of computer assisted tomography (J Comput Assist Tomogr), published in United States. (Language: eng)

Reference: -2009 Sep-Oct; vol 33 (issue 5) : pp 795-8

Dates: Created 2009/10/12; Completed 2009/11/02;

PMID: 19820514, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.