Circulating T-regulatory cells, exercise and the elite adolescent swimmer.

Full Abstract

Brief high intensity exercise induces peripheral leukocytosis possibly leading to a higher incidence of allergic symptoms in athletes undergoing excessive training. We studied the exercise-induced alternation of circulating Tregs and FoxP3+ Tregs due to acute intense swim exercise in elite swimmers (n = 22, 12 males, age = 15.4 yrs). Twelve had prior or current rhinitis or asthma and 10 had no current or prior allergy or asthma. Circulating Tregs increased significantly (p < .001) following exercise (pre = 133 +/- 11.2, post = 196 +/- 17.6) as did FoxP3+ cells (pre = 44, post = 64 cells/microl). Increases in Tregs and FoxP3+ Tregs occurred to the same extent in both groups of adolescent swimmers.

Author information

Author/s: Wilson, Lori D (LD); Zaldivar, Frank P (FP); Schwindt, Christina D (CD); Wang-Rodriguez, Jessica (J); Cooper, Dan M (DM);

Affiliation: Pediatric Exercise Research Center, Department of Pediatrics, University Children's Hospital, University of California, Irvine, CA 92868, USA.

Grants: M01 RR00827 (Agency:NCRR NIH HHS) ; P01HD-048721 (Agency:NICHD NIH HHS) ; R01-HL080947 (Agency:NHLBI NIH HHS) ; T32AR047752 (Agency:NIAMS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Pediatric exercise science (Pediatr Exerc Sci), published in United States. (Language: eng)

Reference: 2009-Aug; vol 21 (issue 3) : pp 305-17

Dates: Created 2009/10/15; Completed 2009/11/03;

PMID: 19827454, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

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